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Tên sản phẩm : OF 200
Composition Each film-coated tablet contains: Ofloxacin USP 200 mg
Ofloxacin Tablets is a broad-spectrum antimicrobial agent for oral administration.
Pharmacodynamic /pharmacologicalproperties After an oral dose, the bioavailability of ofloxacin tablets is about 80%. The maximum plasma concentration achieved 1 to 2 hours after an oral dose. Ofloxacin has biphasic elimination. After the regular dose, the half-period of 4-5 hours and 20-25 hours. Accumulation in stable condition can be assessed semi-period of about 9 hours. Eliminated primarily by the kidneys.
Microbiology Antibacterial spectrum:
These bacteria are considered susceptible to smoking: Staphylococcus aureus (including the resistance methiciline line), Staphylococcus apidermidis, Neisseria gonerrhea, Neisseria meningitidis, E. coli, Citobacter, Hafnia, Proteus (indole line negative and positive), Salmonella , Shigela, Yersinia enterocolitica, Campylobacterae, Chlamydiae, Legionella.
These strains have different expression level of sensitivity: Strerococci, Streptococcus pneumoniae, Streptococcus pyogenes, Acinetobacter, Mycoplsma pneumoniae, Mycobacterium tuberculosis and Mycobacterium fortuitum.
Ofloxacin often have antibacterial activity at concentrations equal to or slightly higher than inhibitory concentrations. Antibacterial effect against susceptible strains is thought to inhibit DNA gyrase, a specific ezym catalyst in the duplication, replication and repair of bacterial DNA
Specify Ofloxacin is indicated for adults with mild to moderate infections caused by susceptible strains as follows:
Acute infections in chronic bronchitis due to Haemophilus influenzae or Streptococcus pneumoniae in 10 days
- Community-acquired pneumonia caused by Haemophilus influezae or Streptococcus pneumoniae in 10 days
- Skin infections caused by Staphylococcus aureus, Streptococcus pyogenes, or Proteus mirabilis in 10 days
- Inflammation of the urethra and gonorrhea caused by Neisseria gonorrhea in 1 day
- Inflammation of the urethra, gonorrhea and cervicitis due to Chlamydia trachomatis in the last 7 days
Mixed infections with gonorrhea and urethritis due to Chlamydia trachomatis and Neisseria gonorrhea in 7 days
- Acute pelvic inflammatory disease due to Chlamydia trachomatis and / or Neisseri gonorrhea in 10-14 days
- Acute uncomplicated urinary bladder caused by Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa in 3 days.
- Urinary tract infection complications di E. coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa in 10 days
- Inflammation of the prostate whether complications due to E. coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa in 10 days
- Intra-abdominal infections caused by Salmonella shigella in 7-10 days.
- Prostatitis due to Escherichia coli in 6 weeks
The appropriate culture and susceptibility testing be performed before treatment in order to isolate and identify the bacteria causing infection and to determine its sensitivity to ofloxacin. The treatment with ofloxacin may be initiated before the results of tests, to know the results, continue treatment with the appropriate regimen. For the other drugs in this class, some strains can Pneumonias aeruginosa resistant hearing rose rapidly during treatment with ofloxacin.
 
Contraindications Hypersensitivity to ofloxacin and other drugs in the quinolone antibiotics
Warning: The safety and effectiveness of ofloxacin for children and teens pregnant women and breast-feeding is established. Convulsions, cranial pressure increased, psychosis poisoning have been reported in patients taking quinolone antibiotics, including ofloxacin.Quinolone also can irritate the central nervous system and lead to tremors, evidence restlessness / agitation, nervousness / anxiety, mild headache, confusion, hallucinations, paranoia, nightmares, insomnia, and rarely have thoughts of suicide or violence. These manifestations may occur after the first dose. If these reactions occur with ofloxacin, the drug should be discontinued and appropriate use of alternative regimens. The severe hypersensitivity or sometimes death can occur when taking quinolone antibiotics, including ofloxacin, or due to certain unknown reasons. These reactions usually occur after an oral dose, the drug should be discontinued immediately if they develop a skin rash or any other sign of hypersensitivity.
Pseudomembranous colitis patients membranes are reported with almost all antibiotics, including ofloxacin, and to be the boss in severity from moderate to risk death. Therefore, need to be diagnosed in patients that diarrhea after taking any antibiotic.
Carefully General: Patients should have adequate water treatment with ofloxacin to avoid formation of high concentrations in the urinary tract. Ofloxacin should be used carefully in patients with renal or bowel. In these patients, the clinical observations thoroughly before and during treatment for potential drug excretion will reduce. For patients with renal impairment in urinary creatine clearance levels 50mg/ml, it should change the mode dose. The reaction of both light and serious poisoning are known in patients exposed to sunlight while taking quinolone antibiotics. Therefore we should avoid sunlight while taking this group, and if any light poisoning occurs, you should stop taking medication ngay.Ofloxacin should be used with caution in people with or suspected CNS disorders Committees.
Drug interactions: when used quinolone general with antacids contains canci, magnesium or aluminum, or iron, or multivitamins containing zinc ... it can affect absorption. Do not take this medication approximately 2 hours before or after taking ofloxacin.
Cimetidine: Cimetidine can affect the excretion of the drug in the quinolone group and as a result increase the half-period and AUC of some quinolones.
Dosage Oral 400 mg every 12 hours. This recommendation applies to patients with normal renal function.
Do not want to effect/side effects From clinical studies show that the following expression in patients may be related to the drug, ofloxacin many times: nausea 3%, insomnia 7%, headache 1%, diarrhea 1%, 1 screen%, pruritus 1%, external genital itching in women 1%, 1% disorder.
Women whoarepregnant/lactating Do not use
Packing Box of10blistersx10tablets
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